Alzheimer’s disease can appear after infection with the varicella zoster virus – Futura

Announced nearly 225,000 people in France Alzheimer’s disease Every year, after the age of 65. Although this type of dementia is common, its origin is still hotly debated among specialists. There are all the same points of consensus: amyloid plaques and clusters tau protein in the structure of neurons
Each neuron consists of:
a cell body or pericarion containing the nucleus; Too many dendrites of the dendritic type (hence…”data-image=”data-url=”data-more=”read more”>nervous cells involved in the onset of symptoms typical of Alzheimer’s disease, andignition that handles the function of the brain
The brain is located in the cranial box, which is the seat of higher functions (cognitive functions, senses, neurological responses) and vegetative functions. So it is an essential device that ensures that all… “data-image =” data-url = “data-more =” read more “>brain This toxicity is also dependent on the dose of the xenbiotic needed for… “data-image=”data-url=”data-more=”read more”>Poisoning.

To explain these notes, Several hypotheses have been proposed by scientists. factors hereditary It appears to have an important role in sporadic cases of Alzheimer’s disease, the most common, but a defect in the synthesis of amyloid proteins or interference with this term includes a variety of very different species, whether prokaryotes (bacteria) or eukaryotes (yeast, algae). … “data-image =” data-url = “data-more =” read more “>microorganisms Most of the time a virus can have an underlying effect.

Experiments in the laboratory on cultured neurons

A team from Tufts University in the US presented findings that fall within the “viral hypothesis” about the origin of Alzheimer’s disease. The latter states that there is a virus in a deep sleep In the brain – two types of herpes simplex virus are most often found: hsv1 and hsv2. Their shape and organization of their RNA is similar, 50% of their DNA is…”data-url=”data-more=”read more”>herpes Virus 1 or HSV-1 – “wakes up” due to factors that are still poorly defined, and leads to symptoms of Alzheimer’s disease. ” Our results indicate a pathway to Alzheimer’s disease induced by the characteristics of Varicella Zoster Virus
Like all viruses of the family Herpesviridae and more specifically of the genus Varicellovirus, the … “data-image=”data-url=”data-more=”read more”>VZV It causes inflammation that awakens HSV-1 in the brain Dana Kern explains Jobs
Cairns are used to mark tracks in arid and rocky areas or on glaciers. They can… “data-image =” data-url =” data-more =” read more “>cairnsthe first author ofA study published in Alzheimer’s Disease Journal.

To confirm this hypothesis, they infected Stem Cells Human neurons were labeled with viruses and looked for signs specific to Alzheimer’s disease: amyloid plaques and tau clumps, glia (proliferation glial cells in the brain) and neuritis. Their results show that VZV alone does not cause the formation of amyloid plaques and tau clumps, like HSV-1, but rather causes neuroinflammation and glia. This, according to scientists, indicates an indirect action of the VZV virus. In addition, they note that infection of cells, in which HSV-1 is dormant, by VZV reactivates the latter and causes changes typical of Alzheimer’s disease. ” It’s a double whammy from two very common and generally harmless viruses, but lab studies suggest that if additional exposure to VZV awakens dormant HSV-1, it can cause problems. Dana Kearns says.

These experiments alone are not strong enough to confirm a causal relationship between Alzheimer’s disease and VZV and HSV-1 viruses, even if the observations point in this direction. Moreover, the various hypotheses being studied about the origin of Alzheimer’s disease are not necessarily conflicting. Viral infection could be a factor to consider in Alzheimer’s disease, among other things.